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Brand name: Avandia
Generic name: Rosiglitazone
Avandia is used to hold down blood sugar levels in people
with type 2 diabetes (also known as "non-insulin dependent"
or "adult onset" diabetes). Blood sugar levels are
ordinarily controlled by the body's natural supply of insulin,
which helps sugar move out of the bloodstream and into the
cells. In type 2 diabetes, the buildup of sugar in the blood
is often due not to a lack of insulin, but to the body's inability
to make proper use of it. Avandia works first by decreasing
sugar production, then by helping the body make more efficient
use of whatever insulin is available. It does not increase
the actual amount of insulin in circulation. Avandia is a
new type of diabetes medication. It can be used alone or in
conjunction with insulin, metformin (Glucophage), or a member
of the sulfonylurea class of diabetes drugs (Diabinese, Micronase,
Orinase). It takes effect slowly. You may not see a reduction
in blood sugar levels for the first 2 weeks of therapy, and
it may take 2 to 3 months for Avandia to deliver maximum results.
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Most important fact about Avandia
Always remember that Avandia is an aid to, not a substitute
for, good diet, weight loss, and exercise. Failure to follow
a sound diet and exercise plan can lead to serious complications,
such as dangerously high or low blood sugar levels. Remember,
too, that Avandia is not an oral form of insulin, and cannot
be used in place of insulin.
How should you take Avandia ?
Your dose of Avandia may be taken once a day in the morning
or divided in half and taken in the morning and evening, with
or without food.
If you miss a dose of Avandia
Take it as soon as you remember. If it is almost time for
the next dose, skip the one you missed and go back to your
regular schedule. Do not take 2 doses at once.
Storage instructions for Avandia
Store at room temperature in a tight, light-resistant container.
What side effects when taking Avandia may occur ?
Side effects of Avandia cannot be anticipated. If any develop
or change in intensity, inform your doctor as soon as possible.
Only your doctor can determine if it is safe for you to continue
taking Avandia.
More common side effects when taking Avandia may include:
Back pain, fatigue, headache, high blood sugar, low blood
sugar, respiratory tract infections, sinus inflammation, swelling
Less common side effects when taking Avandia may include:
Anemia (low blood cell count), diarrhea
Rare side effects of taking Avandia may include:
Congestive heart failure
Why should Avandia not be prescribed ?
Do not take Avandia if it has ever given you an allergic
reaction.
Special warnings about Avandia
If you have liver disease, you should not take Avandia. Your
doctor will check to make sure your liver function is normal
before prescribing Avandia, then recheck it every 2 months
for the first 12 months and periodically thereafter. Warning
signs of liver damage include nausea, vomiting, abdominal
pain, fatigue, loss of appetite, and dark urine. If you develop
any of these symptoms, tell your doctor immediately. You may
need to discontinue treatment with Avandia.
People taking Avandia in combination with other diabetes
drugs sometimes develop low blood sugar. If this happens,
check with your doctor. The dosage of the other diabetes drug
may have to be reduced.
People with kidney problems can take Avandia, but should
not take Glucophage. If you have poor kidney function, you'll
be unable to take advantage of this combination.
Avandia can increase the chances of conception. Be sure to
use some form of birth control if you don't want a pregnancy.
Avandia won't help type 1 diabetics, who are unable to produce
any insulin at all. Insulin shots are a necessity for this
form of the illness. Nor can Avandia relieve diabetic ketoacidosis
(excessively high sugar levels due to lack of insulin).
Use Avandia with caution if you have a problem with fluid
retention or swelling. Avandia has been known to cause this
problem, which in turn can lead to heart failure. Avandia
should be avoided by anyone who has been diagnosed with heart
failure, and it should be discontinued by anyone who develops
it. Make sure the doctor is aware of any heart problems you
may have. Alert him immediately if you develop symptoms of
heart failure such as fatigue and shortness of breath.
You should be aware that people taking Avandia tend to gain
a little weight, typically around 5 to 10 pounds. The cause
is thought to be a combination of fluid retention and fat
accumulation.
Avandia is not recommended for children under 18.
Possible food and drug interactions when taking Avandia
No drug interactions with Avandia have been reported at this
time.
Special information if you are pregnant or breastfeeding
It's important to maintain normal blood sugar levels while
pregnant, but the safety of Avandia during pregnancy remains
unproven. Since insulin shots are known to be safe, your doctor
may switch you from Avandia to insulin until the baby is born.
It is not known whether Avandia appears in breast milk. Because
many drugs do find their way into breast milk, however, the
safest bet is to avoid taking Avandia while nursing.
Recommended dosages for Avandia
ADULTS
The usual starting dose of Avandia either alone or in combination
with another diabetes drug is 4 milligrams once a day or 2
milligrams twice a day. If your sugar levels remain too high
after 12 weeks of treatment, the doctor may increase your
dose to 8 milligrams once a day or 4 milligrams twice a day.
However, the maximum recommended dose of Avandia in combination
with insulin or a sulfonylurea diabetes drug is 4 milligrams
per day.
Overdosage with Avandia
Although there is no information on the potential results
of Avandia overdose, any medication taken in excess can have
serious consequences. If you suspect an overdose of Avandia,
seek medical attention immediately.
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