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Brand names: Nizoral, Ketoconazole, Fungarest

Generic name: Ketoconazole

Why is Ketoconazole prescribed ?

Ketoconazole, a broad-spectrum antifungal drug available in tablet form, may be given to treat several fungal infections within the body, including oral thrush and candidiasis. Ketoconazole may also be given to treat severe, hard-to-treat fungal skin infections that have not cleared up after treatment with creams or ointments, or the oral drug griseofulvin (Fulvicin, Grisactin).

Most important fact about Ketoconazole

In some people, Ketoconazole may cause serious or even fatal damage to the liver. Before starting to take Ketoconazole, and at frequent intervals while you are taking Ketoconazole, you should have blood tests to evaluate your liver function. Tell your doctor immediately if you experience any signs or symptoms that could mean liver damage: these include unusual fatigue, loss of appetite, nausea or vomiting, jaundice, dark urine, or pale stools.

How should you take Ketoconazole?

Take Ketoconazole exactly as prescribed.

You should keep taking Ketoconazole until tests show that your fungal infection has subsided. If you stop too soon, the infection might return.

You may want to take Ketoconazole Tablets with meals to avoid stomach upset.

Avoid alcohol and do not take with antacids. If antacids are necessary, you should wait 2 to 3 hours before taking them.

If you miss a dose of Ketoconazole

Take the forgotten dose of Ketoconazole as soon as you remember. This will help to keep the proper amount of Ketoconazole in the body. However, if it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take double doses.

Storage instructions for Ketoconazole

Ketoconazole should be stored at room temperature.

What side effects when taking Ketoconazole may occur ?

Side effects from Ketoconazole cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Ketoconazole.

More common side effects when taking Ketoconazole may include:

Nausea, vomiting

Less common side effects when taking Ketoconazole may include:

Abdominal pain, itching

Rare side effects when taking Ketoconazole may include:

Breast swelling (in men), depression, diarrhea, dizziness, drowsiness, fever and chills, headache, hives, impotence, light-sensitivity, rash

Why should Ketoconazole not be prescribed ?

Do not take Ketoconazole if you are sensitive to it or have ever had an allergic reaction to it. Never take Ketoconazole together with Seldane, Hismanal, Halcion, or Propulsid. Rare, but sometimes fatal reactions have been reported when these drugs are combined.

Special warnings about Ketoconazole

In rare cases, people have had anaphylaxis (a life-threatening allergic reaction) after taking their first dose of Ketoconazole.

Observe caution when driving or performing other tasks requiring alertness, due to potential side effects of headache, dizziness, and drowsiness.

Possible food and drug interactions when taking Ketoconazole

If Ketoconazole is taken with certain other drugs, the effects of either could be increased, decreased, or altered.

It is especially important to check with your doctor before combining Ketoconazole with the following:

Alcoholic beverages
Antacids such as Di-Gel, Maalox, Mylanta, and others
Anticoagulants such as Coumadin, Dicumarol, and others
Anti-ulcer medications such as Axid, Pepcid, Tagamet, and Zantac
Astemizole (Hismanal)
Cisapride (Propulsid)
Cyclosporine (Sandimmune, Neoral)
Digoxin (Lanoxin)
Drugs that relieve spasms, such as Donnatal
Isoniazid (Nydrazid)
Methylprednisolone (Medrol)
Midazolam (Versed)
Oral diabetes drugs such as Diabinese and Micronase
Phenytoin (Dilantin)
Rifampin (Rifadin, Rifamate, and Rimactane)
Tacrolimus (Prograf)
Terfenadine (Seldane)
Theophyllines (Slo-Phyllin, Theo-Dur, others)
Triazolam (Halcion)

Special information if you are pregnant or breastfeeding

If you are pregnant or plan to become pregnant, inform your doctor immediately. Ketoconazole should be taken during pregnancy only if the benefit outweighs the possible harm to your unborn child. Since Ketoconazole can probably make its way into breast milk, Ketoconazole should not be taken during breastfeeding. If you are a new mother, check with your doctor. You may need to stop breastfeeding while you are taking Ketoconazole.

Recommended dosages for Ketoconazole

ADULTS

The recommended starting dose of Ketoconazole is a single daily dose of 200 milligrams (1 tablet).
In very serious infections, or if the problem does not clear up within the expected time, the dose of Ketoconazole may be increased to 400 milligrams (2 tablets) once daily. Treatment lasts at least 1 to 2 weeks, and for some infections much longer.

CHILDREN

In small numbers of children over 2 years of age, a single daily dose of 3.3 to 6.6 milligrams per 2.2 pounds of body weight has been used. Ketoconazole has not been studied in children under 2 years of age.

Overdosage with Ketoconazole

Although no specific information is available, any medication taken in excess can have serious consequences. If you suspect an overdose of Ketoconazole, seek medical attention immediately.

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