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Generic name: Sibutramine

Brand names: Reductil - Meridia - Sibutramine

Sibutramine helps the seriously overweight shed pounds and keep them off. Sibutramine is especially recommended for those who in addition to being overweight have other health problems such as high blood pressure, diabetes, or high cholesterol. Sibutramine is used in conjunction with a low-calorie diet. Sibutramine works by boosting levels of certain chemical messengers in the nervous system, including serotonin, dopamine, and norepinephrine.

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Most important fact about Sibutramine

Make a point of keeping follow-up appointments with your doctor. Sibutramine can increase your blood pressure, so it's important to have your blood pressure and pulse monitored at the beginning of therapy and regularly thereafter.

How should you take Sibutramine ?

Sibutramine can be taken with or without food.

If you miss a dose of Sibutramine

Take Sibutramine as soon as you remember. If Sibutramine is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.

Storage instructions for Sibutramine

Store at room temperature away from heat and moisture in a tight, light-resistant container.

What side effects when taking Sibutramine may occur ?

Side effects of Sibutramine cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Sibutramine.

More common side effects when taking Sibutramine may include:

Abdominal pain, acid indigestion, anxiety, back pain, constipation, cough increase, depression, dizziness, dry mouth, flu symptoms, headache, increased appetite, insomnia, joint pain, loss of appetite, loss of strength, nasal inflammation, nausea, nervousness, painful menstruation, rash, sinus inflammation, stomachache, sore throat.

Less common side effects when taking Sibutramine may include:

Acne, abnormal thinking, agitation, allergic reaction, arthritis, bronchitis, changes in taste, chest pain, dental problems, diarrhea, difficulty breathing, drowsiness, ear pain, ear problems, emotional changes, fever, gas, heavy uterine bleeding, herpes simplex virus, increased heart rate, increased blood pressure, itching, laryngitis, leg cramps, menstrual problems, migraine headache, muscle ache, neck pain, rectal problems, reduced vision, stimulation, stomach and intestinal inflammation, sweating, swelling, thirst, throbbing heartbeat, tingling skin sensation, urinary tract infection, vaginal yeast infection, vomiting.

Rare side effects when taking Sibutramine may include:

Bleeding problems, kidney problems, seizures

Why should Sibutramine not be prescribed ?

If Sibutramine gives you an allergic reaction, you won't be able to use Sibutramine. You should also avoid Sibutramine (and certainly don't need it) if you suffer from the compulsive dieting disorder known as anorexia nervosa. Do not combine Sibutramine with other drugs used to suppress appetite, and do not use Sibutramine within 2 weeks of taking a drug classified as an MAO inhibitor, including the antidepressant medications Marplan, Nardil, and Parnate.

Special warnings about Sibutramine

Use Sibutramine with caution if you have uncontrolled high blood pressure; Sibutramine could make the problem worse. Avoid Sibutramine completely if you've had a stroke or suffer from heart disease, heart failure, or irregular heartbeat. Also avoid Sibutramine if you have severe kidney or liver problems; Sibutramine has not been tested under these conditions. Seizures are a rare, but possible, side effect. If you've had seizures in the past, use Sibutramine with caution. If you have a seizure while taking Sibutramine, stop using it and call your doctor immediately.

Any drug that acts on the nervous system can theoretically impair judgment, thinking, and motor skills. Sibutramine does not seem to have this effect, but caution is still in order until you know how Sibutramine affects you.

If you have narrow-angle glaucoma or thyroid problems, make sure the doctor knows; Sibutramine should be used with caution in these circumstances. If you are prone to gallstones, be aware that weight loss can cause more of them to form. Sibutramine has not been tested in people under 16 years old. Sibutramine should be used with caution in those over 65. Although Sibutramine has been classified as a controlled substance (potentially subject to abuse), the possibility of developing physical or psychological dependence is low.

Possible food and drug interactions when taking Sibutramine

Remember that Sibutramine must never be taken within 2 weeks of using an MAO inhibitor such as Marplan, Nardil, or Parnate. The combination could lead to serious, even fatal, overstimulation.

Sibutramine may also interact with a wide variety of other prescription and over-the-counter drugs, especially weight-reducing agents, decongestants, antidepressants, allergy medications, and cough and cold remedies that contain ephedrine or pseudoephedrine.

Among the many drugs that pose a potential problem with Sibutramine are the following:

Alcohol (excessive amounts)
Dextromethorphan (found in many over-the-counter cough preparations)
Dihydroergotamine (D.H.E. Injection, Migranal Nasal Spray)
Erythromycin (Eryc, Ery-Tab, PCE)
Fentanyl (Duragesic)
Fluoxetine (Prozac)
Fluvoxamine (Luvox)
Ketoconazole (Nizoral)
Lithium (Eskalith, Lithobid)
Meperidine (Demerol)
Naratriptan (Amerge)
Paroxetine (Paxil)
Pentazocine (Talwin NX, Talacen)
Sertraline (Zoloft)
Stimulants such as amphetamines, Dexedrine, Desoxyn, Adderall, Didrex, and Ionamin
Sumatriptan (Imitrex)
Tryptophan (L-Tryptophan)
Venlafaxine (Effexor)
Zolmitriptan (Zomig)

If you have any doubt about the safety of a combination, be sure to check with your doctor.

Special information on Sibutramine if you are pregnant or breastfeeding

The use of Sibutramine during pregnancy is not recommended. If you are in your child-bearing years, take reliable contraceptive measures while using Sibutramine. If you do become pregnant, or plan on becoming pregnant, tell your doctor immediately. Sibutramine is not known whether Sibutramine appears in breast milk; Sibutramine´s use while breastfeeding is not recommended.

Recommended dosages for Sibutramine

ADULTS

The starting dose of Sibutramine is 10 milligrams once daily. If you have not lost at least 4 pounds after 4 weeks, the doctor may increase the dose to 15 milligrams daily. This is the maximum; if weight loss still fails to appear, Sibutramine will be discontinued.

For those who experience side effects at the 10-milligram level, a 5-milligram dose may prove sufficient.

Use of Sibutramine for longer than 1 year has not been studied.

Overdosage with Sibutramine

Although doctors have had little experience with overdoses of Sibutramine, increased heart rate and blood pressure are possible results. Since any medication taken in excess can have serious consequences, seek medical attention immediately if you suspect an overdose of Sibutramine.

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