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Brand names: Xenical - Orlistat
Generic name: Orlistat
Xenical blocks absorption of dietary fat into the bloodstream,
thereby reducing the number of calories you get from a meal.
At the usual dosage level, Xenical cuts fat absorption by
almost one-third. Combined with a low-calorie diet, Xenical
is used to promote weight loss and discourage the return of
unwanted pounds. Xenical is prescribed for the frankly obese
and for merely overweight people who have other health problems
such as high blood pressure, diabetes, or high cholesterol
levels. Your weight status is determined by your body mass
index (BMI), a comparison of height to weight.
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Most important fact about Xenical
Along with dietary fat, Xenical decreases the absorption
of some fat-soluble vitamins and beta-carotene. To compensate,
you should take a multivitamin containing vitamins A, E, D,
and K once a day, at least 2 hours before or 2 hours after
taking Xenical.
How should you take Xenical ?
Take a capsule of Xenical during, or up to 1 hour after,
each main meal. You should follow a nutritionally balanced,
low-calorie diet that provides no more than 30 percent of
its calories from fat. If you miss a meal, or the meal contains
no fat, you can skip the accompanying dose of Xenical.
If you miss a dose of Xenical
Resume taking Xenical at the next meal. Don't try to make
up the loss with a double dose. The extra Xenical won't help.
Storage instructions for Xenical
Store at room temperature, in a tightly sealed container.
What side effects when taking Xenical may occur ?
Side effects of Xenical are more common during the first
year of treatment. If any develop or change in intensity,
inform your doctor as soon as possible. Only your doctor can
determine if it is safe for you to continue taking Xenical.
More common side effects when taking Xenical may include:
Abdominal discomfort or pain, anxiety, arthritis, back pain,
diarrhea, dizziness, earache, fatigue, fatty or oily stools,
fecal urgency or incontinence, flu, gas with fecal discharge,
gum problems, headache, increased defecation, menstrual problems,
muscle pain, nausea, oily discharge, rectal discomfort or
pain, respiratory tract infections, skin rash, sleep problems,
tooth problems, urinary tract infections, vaginal inflammation,
vomiting.
Less common side effects when taking Xenical may include:
Dry skin, ear/nose/throat problems, joint disorders
Side effects that usually occur after the first year of treatment
with Xenical include: depression, leg pain, swollen feet,
and tendonitis.
Why should Xenical not be prescribed ?
Do not take Xenical if you suffer from "chronic malabsorption
syndrome" ,a condition that prevents nutrients from passing
from your stomach into your bloodstream, or from cholestasis,
a blockage in the supply of bile needed for digestion. You'll
also need to avoid Xenical if it gives you an allergic reaction.
Special warnings about Xenical
Weight loss with Xenical begins within 2 weeks and continues
for 6 to 12 months. The effect of using Xenical for more than
2 years is still unknown.
Side effects of Xenical such as diarrhea and abdominal pain
may be worse if you continue eating a high fat diet or even
take a high-fat meal. Limit your fat intake.
Your doctor will test your thyroid function before starting
you on Xenical to make sure that your weight problem is not
due to an underactive thyroid gland (hypothyroidism). Xenical
is not an appropriate remedy for this problem.
Xenical increases the likelihood of kidney stones.
Use it
with caution if you have a history of this problem.
If you have diabetes, weight-loss is likely to reduce your
blood sugar levels. If you're taking an oral diabetes medication
or insulin, your dose of Xenical may have to be reduced.
Note that the safety and efficacy of Xenical in children
have not been established.
Possible food and drug interactions when taking Xenical
If Xenical is taken with certain other drugs, the effects
of either could be increased, decreased, or altered.
It is especially important to check with your doctor before
combining Xenical with the following:
Cyclosporine (Neoral and Sandimmune)
Warfarin (Coumadin)
Special information if you are pregnant or breastfeeding
The effects of Xenical during pregnancy have not been adequately
studied and Xenical is not recommended for pregnant women.
If you are pregnant or plan to become pregnant, inform your
doctor immediately. It is not known whether Xenical appears
in breast milk. Do not take Xenical while breastfeeding.
Recommended dosages for Xenical
ADULTS
The recommended dose is one 120 - milligram capsule 3 times
daily with each main meal containing fat.
Overdosage with Xenical
The results of a massive overdose of Xenical are unknown,
although Xenical seems relatively harmless. However, any medication
taken in excess can have serious consequences. If you suspect
an overdose of Xenical, seek medical attention.
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