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Brand name: Zyban
Generic name: Bupropion Hydrochloride
Zyban is a nicotine-free quit-smoking aid. Instead of nicotine,
it contains the same active ingredient as the antidepressant
medication Wellbutrin. It works by boosting the levels of
several chemical messengers in the brain. With more of these
chemicals at work, you experience a reduction in nicotine
withdrawal symptoms and a weakening of the urge to smoke.
More than a third of the people who take Zyban while participating
in a support program are able to quit smoking for at least
1 month. Zyban can also prove helpful when people with conditions
such as chronic bronchitis and emphysema decide it's time
to quit.
Most important fact about Zyban
About 1 person in 1,000 suffers a seizure while taking Zyban.
For this reason, people with epilepsy and certain other disorders
should never take Zyban. Don't share Zyban with friends. Only
a doctor can decide whether it's safe for a particular individual.
How should you take Zyban ?
Treatment with Zybanbegins while you are still smoking. Zyban
needs about a week to reach an effective level in your body;
so to improve your chance of success, you should not attempt
to quit until the second week of treatment. Set a firm date
for quitting. If you are still smoking after that date, your
odds of breaking the habit will be worse. You should keep
taking Zyban for 7 to 12 weeks.
You can use nicotine patches along with Zyban. However, combining
the two treatments can raise your blood pressure, so it's
important to tell your doctor if you plan to use both. Do
not smoke while using a patch, because too much nicotine can
cause serious side effects.
Participating in a counseling or support program will make
success more likely. Your doctor can recommend a local program
for you.
Swallow Zyban tablets whole. Do not chew, divide, or crush
them. Take them exactly as prescribed.
If you miss a dose of Zyban
Do not take an extra tablet of Zyban to "catch up"
for the missed dose. Skip the dose and take your next Zyban
tablet at the regularly scheduled time.
Storage instructions for Zyban
Store at room temperature in a tightly closed container.
Keep out of direct sunlight.
What side effects when taking Zyban may occur ?
Side effects of Zyban cannot be anticipated. If any develop
or change in intensity, inform your doctor as soon as possible.
Only your doctor can determine if it is safe for you to continue
taking Zyban.
The most common side effects when taking Zyban are:
Dry mouth and sleeplessness
These are generally mild and usually disappear after a few
weeks. If you have difficulty sleeping, avoid taking Zyban
close to bedtime and ask your doctor about reducing your dosage.
More common side effects when taking Zyban may include:
Abdominal pain, abnormal dreams, anxiety, constipation, diarrhea,
disturbed concentration, dizziness, joint pain, increased
cough, itching, nasal inflammation, nausea, nervousness, rash,
sore throat.
Less common side effects when taking Zyban may include:
Abnormal thinking, allergic reaction, bronchitis, changes
in taste, difficulty breathing, dry skin, fever, hives, hot
flashes, increased appetite or loss of appetite, increased
blood pressure, migraine, mouth ulcers, muscle pain, neck
pain, nosebleed, ringing in the ears, shakiness, sinus inflammation,
sleepiness, throbbing heartbeat.
Rare side effects when taking Zyban may include:
Chest pain, feeling of unhappiness, thirst, swelling of the
face.
Why should Zyban not be prescribed ?
Because Zyban has been known to trigger convulsions, no one
with a seizure disorder should take Zyban. Also avoid Zyban
if you are taking Wellbutrin or any other drug that contains
bupropion, Zyban's active ingredient. The more bupropion you
take, the more likely you are to have a seizure.
Zyban's seizure-triggering potential is greater in people
with an eating disorder such as bulimia or anorexia, and in
those undergoing abrupt withdrawal from alcohol, sedatives,
and tranquilizers such as Librium and Valium. If you suffer
from one of these problems, never take Zyban. Avoid it, too,
if you are taking a drug classified as an MAO inhibitor, such
as the antidepressants Nardil and Parnate. Allow at least
14 days to pass between taking one of these drugs and starting
your Zyban therapy.
If bupropion or any other ingredient in Zyban has ever given
you an allergic reaction, Zyban is not for you.
Special warnings about Zyban
Because the chance of a seizure from Zyban rises with the
amount in your system, never take more than one 150-milligram
tablet at a time, and limit your total daily intake to 2 doses
(300 milligrams).
A variety of conditions can predispose you to seizures, including:
Prior head injuries
Prior seizures
Central nervous system tumors
Cirrhosis of the liver
Too much alcohol
Abrupt withdrawal from alcohol, tranquilizers, or sedatives
Addiction to narcotics or cocaine
Use of over-the-counter stimulants or diet pills
Use of diabetes medications
Use of antidepressants, major tranquilizers, steroids, or
theophylline
If any of these apply to you, use Zyban with care. If you
do have a seizure while taking Zyban, stop taking Zybanand
never take it again.
Stop taking Zyban and call your doctor immediately if you
have difficulty breathing or swallowing; notice swelling in
your face, lips, tongue, or throat; develop swollen arms and
legs; or break out with itchy eruptions. These are warning
signs of a potentially severe allergic reaction.
If you have a liver or kidney condition, make sure the doctor
is aware of it. Your dosage of Zyban may need to be reduced.
(If you have severe cirrhosis of the liver, your dosage must
be reduced.) Also make certain the doctor knows about any
heart condition you may have.
Zyban can interfere with your driving ability. Don't drive
or operate dangerous machinery until you are certain of the
Zyban´s effect on you.
Possible food and drug interactions when taking Zyban
If Zyban is used with certain other drugs, the effects of
either could be increased, decreased, or altered.
It is especially important to check with your doctor before
combining Zyban with the following:
Alcohol
Amantadine (Symmetrel)
Antidepressants such as Norpramin, Pamelor, Paxil, Prozac,
Tofranil, and Zoloft
Beta blockers (heart and blood pressure medications) such
as Inderal, Lopressor, and Tenormin
Carbamazepine (Tegretol)
Cimetidine (Tagamet)
Cyclophosphamide (Cytoxan)
Heart-stabilizing drugs such as Rythmol and Tambocor
Levodopa (Dopar, Larodopa, Sinemet)
Major tranquilizers such as Haldol, Risperdal and Thorazine
MAO inhibitors such as the antidepressants Nardil and Parnate
Orphenadrine (Norflex)
Phenobarbital
Phenytoin (Dilantin)
Steroids such as prednisone and hydrocortisone
Theophylline (Theo-Dur, Theolair)
Quitting smoking, with or without Zyban treatment, could
change the way your body metabolizes certain drugs, for example,
theophylline and warfarin (Coumadin). Make sure your doctor
knows all the prescription and over-the-counter medicines
you're taking.
Special information if you are pregnant or breastfeeding
Zyban has not been tested in pregnant women. If you are pregnant
or plan to become pregnant, do your best to quit smoking with
the aid of counseling and support before turning to Zyban
therapy. For the sake of the baby, you should avoid smoking
or taking nicotine in any other form while pregnant.
Zyban appears in breast milk and could affect a nursing infant.
Ask your doctor whether it will be better to discontinue the
Zyban or to stop breastfeeding.
Recommended dosages for Zyban
ADULTS
The usual starting dose of Zyban is one 150-milligram tablet
in the morning for the first 3 days. After that, take one
150-milligram tablet in the morning and another in the early
evening. Keep doses at least 8 hours apart.
The maximum recommended dose is 300 milligrams daily.
Continue taking Zyban for 7 to 12 weeks. Your doctor may recommend
continuing treatment for up to 6 months.
Kidney and Liver Disease
Your doctor may reduce the frequency of your doses to avoid
high blood levels of Zyban. If you have severe cirrhosis of
the liver, you should take no more than 150 milligrams every
other day.
CHILDREN
The safety and efficacy of Zyban have not been established
in children under 18.
Overdosage with Zyban
Information on Zyban overdose is limited. However, any medication
taken in excess can have serious consequences. If you suspect
an overdose of Zyban, seek medical attention immediately.
Symptoms of Zyban overdose may include:
Blurred vision, confusion, grogginess, jitteriness, light-headedness,
nausea, seizure, sluggishness, visual hallucinations.
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